Search for structurally diverse heterocyclic analogs as dual-acting antimalarial and antileishmanial agents: An overview

Infections caused by protozoan parasites continue to be a significant cause of morbidity and mortality across the globe, with malaria leishmaniasis forming fulcrum these infections. Decreased effectiveness existing drugs increasing cases drug resistance have called for multifaceted approach development safe, efficacious, affordable leishmaniasis. The present review article aims unearth structurally diverse compounds as dual-acting antimalarial antileishmanial agents. current mainly focuses on structure, biological activities, structure-activity relationship (SAR) studies synthetic natural that showed promising potential against Leishmania in past decade (2011–2021).